Drugs Information: Ivosidenib
Basic Information
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| ID | DDInter1000 | |
| Drug Type | small molecule | |
| Molecular Formula | C28H22Clf3N6O3 | |
| Molecular Weight | 582.970 | |
| Description | Ivosidenib is an isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia with a susceptible mutation. | |
| ATC Classification | L01XX62 | |
| IUPAC Name | (2S)-2-(2-Chlorophenyl)-2-{1-[(2S)-1-(4-Cyanopyridin-2-Yl)-5-Oxopyrrolidin-2-Yl]-N-(5-Fluoropyridin-3-Yl)Formamido}-N-(3,3-Diflu | |
| InChI | Inchi=1S/C28H22Clf3N6O3/C29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/H1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/T22-,25-/M0/S1 | |
| InChI Key | WIJZXSAJMHAVGX-DHLKQENFSA-N | |
| Canonical SMILES | [H][C@@](N(C(=O)[C@]1([H])CCC(=O)N1C1=NC=CC(=C1)C#N)C1=CC(F)=CN=C1)(C(=O)NC1CC(F)(F)C1)C1=C(Cl)C=CC=C1 | |
| Useful Links | DrugBank ChEMBL | |
Interactions with Ivosidenib
| Severity level | ID | Name | Mechanism | Detail |
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