Drugs Information: Leuprolide
Basic Information
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| ID | DDInter1042 | |
| Drug Type | small molecule | |
| Molecular Formula | C59H84N16O12 | |
| Molecular Weight | - | |
| Description | Leuprolide is a peptide-based GnRH receptor superagonist used for the palliative treatment of prostate cancer, uterine leiomyomata, endometriosis, and central precocious puberty. | |
| ATC Classification | L02AE51 L02AE02 | |
| IUPAC Name | (2S)-1-[(2S)-5-Carbamimidamido-2-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-3-Hydroxy-2-[(2S)-2-[(2S)-3-(1H-Imidazol-4-Yl)-2-{[(2S)-5-Oxopyrr | |
| InChI | Inchi=1S/C59H84N16O12/C1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/H7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/T40-,41-,42-,43+,44-,45-,46-,47-,48-/M0/S1 | |
| InChI Key | GFIJNRVAKGFPGQ-LIJARHBVSA-N | |
| Canonical SMILES | CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1 | |
| Useful Links | DrugBank ChEMBL | |
Interactions with Leuprolide
| Severity level | ID | Name | Mechanism | Detail |
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