Drugs Information: Lofexidine

Basic Information

ID DDInter1083
Drug Type small molecule
Molecular Formula C11H12Cl2N2O
Molecular Weight 259.136
Description Lofexidine is a centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults.
ATC Classification N07BC04
IUPAC Name 2-[1-(2,6-Dichlorophenoxy)Ethyl]-4,5-Dihydro-1H-Imidazole
InChI Inchi=1S/C11H12Cl2N2O/C1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/H2-4,7H,5-6H2,1H3,(H,14,15)
InChI Key KSMAGQUYOIHWFS-UHFFFAOYSA-N
Canonical SMILES CC(OC1=C(Cl)C=CC=C1Cl)C1=NCCN1
Useful Links DrugBank ChEMBL PubChem

Interactions with Lofexidine

Severity level ID Name Mechanism Detail