Drugs Information: Naldemedine
Basic Information
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| ID | DDInter1258 | |
| Drug Type | small molecule | |
| Molecular Formula | C32H34N4O6 | |
| Molecular Weight | 570.646 | |
| Description | Naldemedine is an opioid antagonist used to to treat opioid-induced constipation. | |
| ATC Classification | A06AH05 | |
| IUPAC Name | (1S,5R,13R,17S)-4-(Cyclopropylmethyl)-10,14,17-Trihydroxy-N-[2-(3-Phenyl-1,2,4-Oxadiazol-5-Yl)Propan-2-Yl]-12-Oxa-4-Azapentacycl | |
| InChI | Inchi=1S/C32H34N4O6/C1-30(2,29-33-27(35-42-29)18-6-4-3-5-7-18)34-28(39)20-15-32(40)22-14-19-10-11-21(37)25-23(19)31(32,26(41-25)24(20)38)12-13-36(22)16-17-8-9-17/H3-7,10-11,17,22,26,37-38,40H,8-9,12-16H2,1-2H3,(H,34,39)/T22-,26+,31+,32-/M1/S1 | |
| InChI Key | AXQACEQYCPKDMV-RZAWKFBISA-N | |
| Canonical SMILES | [H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC(C(=O)NC(C)(C)C1=NC(=NO1)C1=CC=CC=C1)=C2O)=CC=C3O | |
| Useful Links | DrugBank ChEMBL PubChem | |
Interactions with Naldemedine
| Severity level | ID | Name | Mechanism | Detail |
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