|
| ID |
DDInter1303 |
| Drug Type |
small molecule |
| Molecular Formula |
C8H6N4O5 |
| Molecular Weight |
238.159
|
| Description |
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.[L6856,L6859,L6862] Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.[A179824] This drug is more resistant to the development of bacterial resistance because it acts on many targets at once.[A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830]
Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895]
|
| ATC Classification |
J01XE01
J01XE51
|
| IUPAC Name |
1-[(E)-[(5-Nitrofuran-2-Yl)Methylidene]Amino]Imidazolidine-2,4-Dione |
| InChI |
Inchi=1S/C8H6N4O5/C13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/H1-3H,4H2,(H,10,13,14)/B9-3+ |
| InChI Key |
NXFQHRVNIOXGAQ-YCRREMRBSA-N |
| Canonical SMILES |
[O-][N+](=O)C1=CC=C(O1)\C=N\N1CC(=O)NC1=O |
| Useful Links |
DrugBank
ChEMBL
|