Drugs Information: Plicamycin
Basic Information
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| ID | DDInter1484 | |
| Drug Type | small molecule | |
| Molecular Formula | C52H76O24 | |
| Molecular Weight | - | |
| Description | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | |
| ATC Classification | L01DC02 | |
| IUPAC Name | (2S,3S)-3-[(1S,3S,4R)-3,4-Dihydroxy-1-Methoxy-2-Oxopentyl]-2-{[(2S,4R,5R,6R)-4-{[(2S,4R,5S,6R)-4-{[(2S,4S,5R,6R)-4,5-Dihydroxy-4 | |
| InChI | Inchi=1S/C52H76O24/C1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/H10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/T19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43-,44-,45+,49+,50+,51-,52+/M1/S1 | |
| InChI Key | CFCUWKMKBJTWLW-BKHRDMLASA-N | |
| Canonical SMILES | CO[C@@H]([C@@H]1CC2=CC3=CC(O[C@H]4C[C@@H](O[C@H]5C[C@@H](O)[C@H](O)[C@@H](C)O5)[C@H](O)[C@@H](C)O4)=C(C)C(O)=C3C(O)=C2C(=O)[C@H]1O[C@H]1C[C@@H](O[C@H]2C[C@@H](O[C@H]3C[C@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](O)[C@@H](C)O2)[C@H](O)[C@@H](C)O1)C(=O)[C@@H](O)[C@@H](C)O | |
| Useful Links | DrugBank PubChem | |
Interactions with Plicamycin
| Severity level | ID | Name | Mechanism | Detail |
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