|
| ID |
DDInter1582 |
| Drug Type |
small molecule |
| Molecular Formula |
C33H40N2O9 |
| Molecular Weight |
608.688
|
| Description |
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
|
| ATC Classification |
C02LA51
C02AA02
C02LA01
C02LA71
C02AA52
|
| IUPAC Name |
Methyl (1R,15S,17R,18R,19S,20S)-6,18-Dimethoxy-17-(3,4,5-Trimethoxybenzoyloxy)-3,13-Diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{1 |
| InChI |
Inchi=1S/C33H40N2O9/C1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/H7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/T18-,22+,24-,27-,28+,31+/M1/S1 |
| InChI Key |
QEVHRUUCFGRFIF-MDEJGZGSSA-N |
| Canonical SMILES |
[H][C@]12C[C@@H](OC(=O)C3=CC(OC)=C(OC)C(OC)=C3)[C@H](OC)[C@@H](C(=O)OC)[C@@]1([H])C[C@@]1([H])N(CCC3=C1NC1=C3C=CC(OC)=C1)C2 |
| Useful Links |
DrugBank
ChEMBL
PubChem
|