|
| ID |
DDInter1874 |
| Drug Type |
small molecule |
| Molecular Formula |
C14H18N4O3 |
| Molecular Weight |
290.323
|
| Description |
Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707]
|
| ATC Classification |
J01EE03
J01EA01
J04AM08
J01EE01
J01EE04
More
|
| IUPAC Name |
5-[(3,4,5-Trimethoxyphenyl)Methyl]Pyrimidine-2,4-Diamine |
| InChI |
Inchi=1S/C14H18N4O3/C1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/H5-7H,4H2,1-3H3,(H4,15,16,17,18) |
| InChI Key |
IEDVJHCEMCRBQM-UHFFFAOYSA-N |
| Canonical SMILES |
COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC |
| Useful Links |
DrugBank
ChEMBL
|