Drugs Information: Troglitazone

Basic Information

ID DDInter1881
Drug Type small molecule
Molecular Formula C24H27No5S
Molecular Weight 441.548
Description Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].
ATC Classification A10BG01
IUPAC Name 5-({4-[(6-Hydroxy-2,5,7,8-Tetramethyl-3,4-Dihydro-2H-1-Benzopyran-2-Yl)Methoxy]Phenyl}Methyl)-1,3-Thiazolidine-2,4-Dione
InChI Inchi=1S/C24H27No5S/C1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/H5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
InChI Key GXPHKUHSUJUWKP-UHFFFAOYSA-N
Canonical SMILES CC1=C(C)C2=C(CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)O2)C(C)=C1O
Useful Links DrugBank ChEMBL PubChem

Interactions with Troglitazone

Severity level ID Name Mechanism Detail