|
| ID |
DDInter581 |
| Drug Type |
small molecule |
| Molecular Formula |
C19H20N2O3 |
| Molecular Weight |
324.380
|
| Description |
Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is not shown to have activity at other known serotonin receptors, and has low affinity for dopamine receptors.
|
| ATC Classification |
A04AA04
|
| IUPAC Name |
(1S,3R,5R,7S)-10-Oxo-8-Azatricyclo[5.3.1.0³,⁸]Undecan-5-Yl 1H-Indole-3-Carboxylate |
| InChI |
Inchi=1S/C19H20N2O3/C22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17/H1-4,9,11-14,20H,5-8,10H2/T11-,12-,13+,14+ |
| InChI Key |
UKTAZPQNNNJVKR-KJGYPYNMSA-N |
| Canonical SMILES |
[H][C@@]1(C[C@@]2([H])C[C@]3([H])C[C@@]([H])(C1)N2CC3=O)OC(=O)C1=CNC2=C1C=CC=C2 |
| Useful Links |
DrugBank
ChEMBL
|