Drugs Information: Fostamatinib

Basic Information

ID DDInter785
Drug Type small molecule
Molecular Formula C23H26Fn6O9P
Molecular Weight 580.466
Description Fostamatinib is a spleen tyrosine kinase inhibitor used to treat chronic immune thrombocytopenia after attempting one other treatment.
ATC Classification B02BX09
IUPAC Name {[6-({5-Fluoro-2-[(3,4,5-Trimethoxyphenyl)Amino]Pyrimidin-4-Yl}Amino)-2,2-Dimethyl-3-Oxo-2H,3H,4H-Pyrido[3,2-B][1,4]Oxazin-4-Yl]
InChI Inchi=1S/C23H26Fn6O9P/C1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/H6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)
InChI Key GKDRMWXFWHEQQT-UHFFFAOYSA-N
Canonical SMILES COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC
Useful Links DrugBank ChEMBL PubChem

Interactions with Fostamatinib

Severity level ID Name Mechanism Detail