Drugs Information: Imatinib

Basic Information

ID DDInter909
Drug Type small molecule
Molecular Formula C29H31N7O
Molecular Weight 493.615
Description Imatinib is a tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
ATC Classification L01XE01
IUPAC Name N-(4-Methyl-3-{[4-(Pyridin-3-Yl)Pyrimidin-2-Yl]Amino}Phenyl)-4-[(4-Methylpiperazin-1-Yl)Methyl]Benzamide
InChI Inchi=1S/C29H31N7O/C1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/H3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
InChI Key KTUFNOKKBVMGRW-UHFFFAOYSA-N
Canonical SMILES CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC(NC3=NC=CC(=N3)C3=CN=CC=C3)=C(C)C=C2)CC1
Useful Links DrugBank ChEMBL PubChem

Interactions with Imatinib

Severity level ID Name Mechanism Detail