Interaction between Disopyramide and Carteolol
Major
Synergy
| ID | DDInter575 and DDInter303 |
| Interaction | Due to its potent negative inotropic and chronotropic effects, disopyramide has been associated with severe hypotension, syncope, severe bradycardia, asystole, and heart failure when used with beta-blockers. In addition, QT interval prolongation and excessive QRS complex widening may occur with concurrent administration of disopyramide and beta-blockers in the treatment of arrhythmias. The use of disopyramide has been associated with rare cases of significant hypoglycemia. Since beta-blockers may inhibit some of the normal physiologic response to hypoglycemia, glucoregulatory mechanisms (in the absence of food) may be compromised. |
| Management | The use of disopyramide in combination with beta-blockers should generally be avoided unless the benefits are anticipated to outweigh the risks. Close monitoring of cardiac output, blood pressure, heart rate, and/or ECG is recommended if these drugs must be used together. Patients should be advised to seek medical attention if they experience dizziness, lightheadedness, syncope, palpitations, slow or fast pulse, or irregular heartbeats. |
| References | |
| Alternative for Disopyramide |
C01B
|
| Alternative for Carteolol |
S01E
Brinzolamide (ophthalmic)
Brimonidine (topical)
Epinephrine (topical)
Epinephrine
Tafluprost (ophthalmic)
Dipivefrin (ophthalmic)
Dorzolamide (ophthalmic)
Apraclonidine
Bimatoprost
Epinephrine (ophthalmic)
Latanoprostene bunod (ophthalmic)
More
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Potential Metabolism Interactions
Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.