Interaction between Levothyroxine and Orlistat
Moderate
Absorption
| ID | DDInter1064 and DDInter1348 |
| Interaction |
INTERVAL: Orlistat may interfere with the gastrointestinal absorption of levothyroxine and other thyroid hormones. The exact mechanism of interaction is unknown.
abdominal pain
acute pancreatitis
allergic rhinitis
Amnesia
appendicitis
asthma
Ataxia
atrioventricular block
bipolar disorder
blepharoptosis
More
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| Management | Orlistat and oral thyroid hormone preparations should be administered at least 4 hours apart. Close clinical and laboratory monitoring of thyroid function is recommended. Patients should be advised to contact their physician if they experience symptoms of hypothyroidism such as fatigue, muscle weakness or pain, joint stiffness, depression, constipation, hoarseness, weight gain, hair loss, brittle nails, pale or dry skin, cold intolerance, memory problems, confusion, or menstrual irregularities. |
| References | |
| Alternative for Levothyroxine | - |
| Alternative for Orlistat |
A08A
|
Potential Metabolism Interactions
Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.