Interaction between Oseltamivir and Warfarin
Minor
Others
| ID | DDInter1350 and DDInter1951 |
| Interaction |
Limited data suggest that oseltamivir may potentiate the hypoprothrombinemic effect of warfarin. The mechanism of interaction is unknown, as oseltamivir has not been shown to interfere with coagulation or inhibit any CYP enzymes, specifically those involved in the metabolism of warfarin. Moreover, stress and infection can also affect coagulation, as well as fever and dietary changes associated with illness. In the absence of strong evidence or a biologically plausible mechanism, the risk of interaction between oseltamivir and warfarin appears to be low.
agranulocytoses
Anorexia
aortic stenosis
asthenia
atrial flutter
bacterial pneumonia
Clotting
Candida Infection
cerebral infarct
constipated
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| Management | - |
| References | |
| Alternative for Oseltamivir |
J05A
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| Alternative for Warfarin |
B01A
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Potential Metabolism Interactions
Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.