Interaction between Methohexital and Isocarboxazid
Major Others

ID DDInter1173 and DDInter981
Interaction Anecdotal reports have implicated the concomitant use of general anesthesia and nonselective monoamine oxidase inhibitors (MAOIs) as causing hypotension or hypertension. Analysis of these cases suggests that other contributing factors may have been involved (e.g., meperidine and sympathomimetic agents).
Management The makers of MAOIs, both selective and nonselective, consider general anesthesia to be contraindicated in patients treated with MAOIs and recommend discontinuing MAOI therapy 10 to 14 days before elective surgery.
References
Alternative for Methohexital N05C
Dichloralphenazone
Zopiclone
Nitrazepam
Ethchlorvynol
Scopolamine (ophthalmic)
Melatonin

N01A
Alternative for Isocarboxazid N06A
Citalopram
Esketamine
St. John's Wort
Vortioxetine
Tryptophan
Bupropion
Mirtazapine
Maprotiline
Milnacipran
Vilazodone
Desvenlafaxine
More

Potential Metabolism Interactions

Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.