Interaction between Ketorolac and Pentoxifylline
Major
Synergy
ID | DDInter1010 and DDInter1426 |
Interaction |
The concomitant use of pentoxifylline and ketorolac may increase the risk of bleeding. Bleeding events have been reported in postoperative patients who were receiving both drugs, although causality was not established. Pentoxifylline and ketorolac individually have been associated with prothrombin time prolongations and bleeding.
anaemia
asthenia
allergic dermatitis
black stools
Gastric Cancer
|
Management | Concurrent use is considered contraindicated. |
References | |
Alternative for Ketorolac |
M01A
Flurbiprofen (ophthalmic)
Misoprostol
Chondroitin sulfate
Esomeprazole
Glucosamine
Suprofen (ophthalmic)
S01F
More
|
Alternative for Pentoxifylline |
C04A
R03D
More
|
Potential Metabolism Interactions
Substrate-Substrate Interaction:If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction:Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction:Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.