Interaction between Fluvoxamine and Diazepam
Major
Metabolism
| ID | DDInter770 and DDInter534 |
| Interaction |
One study has reported that fluvoxamine significantly decreases the clearance of diazepam and desmethyldiazepam in healthy volunteers. The mean half-life of diazepam increased from 51 hours to 118 hours. The mechanism is inhibition of hepatic CYP450 metabolism. Other benzodiazepines that are metabolized by this route may also be affected.
abdominal distension
abdominal pain
anaemia
anaemia hypochromic
asthma
bipolar disorder
Blepharospasm
bruxism
chest pain
pleural pain
More
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| Management | The manufacturer states that fluvoxamine and diazepam should not be given together. Lorazepam, oxazepam, and temazepam are metabolized by glucuronidation and are not expected to be affected by fluvoxamine. |
| References | |
| Alternative for Fluvoxamine |
N06A
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| Alternative for Diazepam | - |
Potential Metabolism Interactions
Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.