Interaction between Midodrine and Bupropion
Moderate Synergy

ID DDInter1213 and DDInter252
Interaction Midodrine, an alpha-1 adrenergic agent may lead to bradycardia if administered concomitantly with any agent that directly or indirectly reduces heart rate. This may be most important for beta blockers and tricyclic antidepressants.
anaemia dehydration failure to thrive gastrointestinal bleed haemorrhoids Hepatitis C Chronic Kidney Disease lower GI bleeding nausea Neutropenia More
Management Patients should be advised to discontinue midodrine if they experience signs or symptoms of decreased heart rate (i.e., slow pulse, dizziness, syncope, cardiac awareness) and to contact their provider for reevaluation.
References
Alternative for Midodrine C01C
Milrinone
Angiotensin II
Phenylephrine (topical)
Mephentermine
Norepinephrine
Dobutamine
Amrinone
Arbutamine
Phenylephrine
Phenylephrine (nasal)
Droxidopa
More
Alternative for Bupropion A08A
Dexfenfluramine
Naltrexone
Fenfluramine
Orlistat

N06A
Vortioxetine
Trazodone
Esketamine
Tryptophan
St. John's Wort
Fluvoxamine
Clomipramine
More

Potential Metabolism Interactions

Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.