Interaction between Bupropion and Ozanimod
Major Synergy

ID DDInter252 and DDInter1376
Interaction Coadministration of bupropion with other drugs that also inhibit the reuptake of dopamine or norepinephrine, including monoamine oxidase inhibitors (MAOIs), may increase the risk of hypertensive reactions. Additionally, MAOIs can increase dopaminergic and noradrenergic activity by inhibiting the metabolism of dopamine and norepinephrine.
Management Concurrent use of bupropion with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, procarbazine) is considered contraindicated. At least 14 days (or 24 hours for reversible MAOIs such as moclobemide and linezolid) should elapse between discontinuation of MAOI therapy and initiation of treatment with bupropion. Conversely, at least 14 days should elapse after discontinuation of bupropion and initiation of MAOI therapy.
References
Alternative for Bupropion A08A
Orlistat

N06A
Esketamine
Alternative for Ozanimod L04A
Alefacept
Canakinumab
Certolizumab pegol
Cladribine
Efalizumab
Antithymocyte immunoglobulin (rabbit)
Secukinumab
Brodalumab
Natalizumab
Mycophenolic acid
Ixekizumab
More

Potential Metabolism Interactions

Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.