Interaction between Cyclosporine and Ezetimibe
Moderate Others

ID DDInter458 and DDInter707
Interaction Coadministration with cyclosporine may significantly increase the plasma concentrations of ezetimibe. The mechanism of interaction is unknown.
abdominal distension abdominal pain adenocarcinoma alcohol consumption Amnesia Anorexia Aching joints arthritis ascites AFIB More
Management Caution is advised if ezetimibe is prescribed to patients receiving cyclosporine due to the potential for increased exposure to ezetimibe and altered exposure to cyclosporine. This exposure may be greater in patients with severe renal impairment. Monitoring of cyclosporine concentrations is recommended.
References
Alternative for Cyclosporine L04A
Rilonacept
Certolizumab pegol
Guselkumab
Anakinra
Canakinumab
Alemtuzumab
Dimethyl fumarate
Infliximab
Golimumab
Efalizumab
Tofacitinib
More
Alternative for Ezetimibe C10B

C10A
Colestipol
Cholestyramine
Bempedoic acid
Dextrothyroxine

Potential Metabolism Interactions

Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.