Interaction between Tranylcypromine and Yohimbine
Moderate
Others
| ID | DDInter1845 and DDInter1954 |
| Interaction | Theoretically, yohimbine may precipitate severe hypertensive reactions and hyperpyrexia in patients treated with monoamine oxidase inhibitors (MAOIs). Yohimbine has been shown to induce the release of norepinephrine in patients with essential hypertension. This action could produce a synergistic sympathomimetic effect with MAOIs, which enhance norepinephrine storage in adrenergic neurons. |
| Management | While clinical data are lacking, yohimbine should preferably not be used with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, procarbazine). At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with yohimbine. |
| References | |
| Alternative for Tranylcypromine |
N06A
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| Alternative for Yohimbine |
G04B
Phenazopyridine
Calcium chloride
Phenyl salicylate
Acetohydroxamic acid
Pentosan polysulfate
Dimethyl sulfoxide
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Potential Metabolism Interactions
Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.