Interaction between Minoxidil (topical) and Alprostadil
Moderate
Synergy
| ID | DDInter1227 and DDInter55 |
| Interaction | Theoretically, topical administration of minoxidil may potentiate the hypotensive effects of systemic minoxidil and other vasodilators. Increased systemic absorption may occur when topical minoxidil is used in excess of normally recommended dosages or applied to compromised skin. |
| Management | Patients prescribed topical minoxidil in combination with systemic vasodilators or peripherally-acting antiadrenergic agents should be monitored for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache. |
| References | |
| Alternative for Minoxidil (topical) |
D11A
Pimecrolimus (topical)
Alitretinoin (topical)
Ivermectin (topical)
Magnesium sulfate
Finasteride
Aminobenzoic acid
More
|
| Alternative for Alprostadil |
C01E
G04B
More
|
Potential Metabolism Interactions
Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.