Drugs Information: Vemurafenib

Basic Information

ID DDInter1925
Drug Type small molecule
Molecular Formula C23H18Clf2N3O3S
Molecular Weight 489.930
Description Vemurafenib is a kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation.
ATC Classification G01AE10 L01XE15
IUPAC Name N-{3-[5-(4-Chlorophenyl)-1H-Pyrrolo[2,3-B]Pyridine-3-Carbonyl]-2,4-Difluorophenyl}Propane-1-Sulfonamide
InChI Inchi=1S/C23H18Clf2N3O3S/C1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/H3-8,10-12,29H,2,9H2,1H3,(H,27,28)
InChI Key GPXBXXGIAQBQNI-UHFFFAOYSA-N
Canonical SMILES CCCS(=O)(=O)NC1=C(F)C(C(=O)C2=CNC3=NC=C(C=C23)C2=CC=C(Cl)C=C2)=C(F)C=C1
Useful Links DrugBank ChEMBL PubChem

Interactions with Vemurafenib

Severity level ID Name Mechanism Detail