Interaction between Levodopa and Citicoline
Minor Synergy

ID DDInter1054 and DDInter389
Interaction Citicoline may enhance the effects of levodopa. The exact mechanism is unknown, but animal models suggest that citicoline may increase dopamine levels in the brain and/or improve dopaminergic cell survival. However, data are limited.
Management -
References
Alternative for Levodopa N04B
Entacapone
Cabergoline
Opicapone
Ropinirole
Safinamide
Bromocriptine
Amantadine
Rotigotine
Pergolide
Selegiline
Tolcapone
More
Alternative for Citicoline N06B
Metamfetamine
Methylphenidate
Pemoline
Dexmethylphenidate
Modafinil
Caffeine
Dextroamphetamine
Lisdexamfetamine
Atomoxetine
Armodafinil

Potential Metabolism Interactions

Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.