Interaction between Desmopressin and Methylprednisolone
Major
Synergy
| ID | DDInter507 and DDInter1191 |
| Interaction | Coadministration of desmopressin with loop diuretics or systemic or inhaled corticosteroids may increase the risk of severe hyponatremia. Loop diuretics and corticosteroids can potentiate the antidiuretic response to desmopressin by causing loss of sodium and water retention, respectively, thus coadministration may increase the risk of water intoxication and hyponatremia. Elderly patients may be particularly susceptible. |
| Management | Concomitant use of certain desmopressin products with loop diuretics or systemic or inhaled corticosteroids is considered contraindicated. Please consult individual product labeling for specific recommendations. Caution is advised when coadministration is required. Serum electrolytes, especially sodium, as well as BUN and creatinine should be monitored regularly and as often as clinically appropriate based on individual risk factors. Patients should be advised to seek medical attention if they develop signs and symptoms of water intoxication or hyponatremia such as anorexia, nausea, vomiting, headache, malaise, lethargy, irritability, difficulty concentrating, memory impairment, confusion, weakness, muscle spasm, unsteadiness (which may lead to falls), anuria, and weight gain. Severe hyponatremia can be life-threatening if it is not promptly diagnosed and treated; therefore, early treatment is important to help prevent progression to seizures, coma, respiratory arrest, and death. |
| References | |
| Alternative for Desmopressin |
H01B
|
| Alternative for Methylprednisolone |
D10A
Dexamethasone (ophthalmic)
Clindamycin (topical)
Fluorometholone
Tretinoin
Clindamycin
Dexamethasone (topical)
More
|
Potential Metabolism Interactions
Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.