Interaction between Sertraline and Polyethylene glycol (3350)
Moderate Synergy

ID DDInter1662 and DDInter1488
Interaction Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in patients treated with drugs that prolong the QT interval. Electrolyte disturbances including hypokalemia and hypomagnesemia have been reported with laxative abuse and are known risk factors for torsade de pointes associated with QT interval prolongation.
Management Patients treated with drugs that prolong the QT interval should exercise caution when self-medicating with laxatives. The recommended dosage and duration of use should not be exceeded. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.
References
Alternative for Sertraline N06A
St. John's Wort
Trimipramine
Bupropion
Maprotiline
Desvenlafaxine
Oxitriptan
Vilazodone
Tranylcypromine
Amoxapine
Doxepin (topical)
Desipramine
More
Alternative for Polyethylene glycol (3350) A06A
Naldemedine
Methylnaltrexone
Linaclotide
Methylcellulose
Prucalopride
Naloxone
Magnesium carbonate
Magnesium oxide
Magnesium sulfate
Lubiprostone
Sorbitol
More

Potential Metabolism Interactions

Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.