Interaction between Metformin and Hydrocortisone (topical)
Minor
Antagonism
| ID | DDInter1164 and DDInter887 |
| Interaction |
The efficacy of insulin and other antidiabetic agents may be diminished by topical corticosteroids, particularly during prolonged or indiscriminate use. Corticosteroids can raise blood glucose level by antagonizing the action and suppressing the secretion of insulin, which results in inhibition of peripheral glucose uptake and increased gluconeogenesis. The duration of administration Close clinical monitoring of glycemic control is recommended if topical corticosteroids are administered chronically and/or to large areas in diabetic patients.
abdominal pain
anaphylactic reaction
anaemia
angina
angioedema
apraxia
Arrhythmia
arteriosclerosis
ascites
asthenia
More
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| Management | - |
| References | |
| Alternative for Metformin |
A10B
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| Alternative for Hydrocortisone (topical) |
S01C
Fluocinolone acetonide
Prednisolone (ophthalmic)
Fluorometholone (ophthalmic)
Dexamethasone (nasal)
Diclofenac (ophthalmic)
Fluorometholone
A01A
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Potential Metabolism Interactions
Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.