Interaction between Furosemide and Teriparatide
Minor
Others
ID | DDInter790 and DDInter1772 |
Interaction | The concomitant administration of intravenous furosemide 20 mg to 100 mg and teriparatide did not significantly affect calcium response in normal subjects or patients with mild to severe renal insufficiency. Serum calcium increased by 2% and urinary excretion of calcium by 37% (clinically insignificant). No action is necessary. |
Management | - |
References | |
Alternative for Furosemide |
C03E
C03C G01A
More
|
Alternative for Teriparatide |
H05A
|
Potential Metabolism Interactions
Substrate-Substrate Interaction:If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction:Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction:Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.